Observational heritability at Cornell

Observational heritability of 160 traits pulled from the diagnoses codes and clinical pathology reports at Weil Cornell Medical Center. The following traits passed both stages of QC analysis. For a list of all traits that passed stage 1 (N=311) of QC download the Supplemental Data Files from the main page.

trait type trait trait code sampling size posa n sig h2s h2o h2o solar error h2o solar pvalue h2o strap lo h2o strap hi
lab Leukocytes 6690-2 4000 1.00 200 0.31 0.05 5.72e-09 0.16 0.40
lab Neutrophils/100 leukocytes 26511-6 9000 0.99 199 0.15 0.04 1.77e-05 0.09 0.22
icd9 V72.2 1000 1.00 57 0.85 0.15 8.24e-13 0.69 0.98
icd9 V70.9 2000 0.89 177 0.36 0.03 4.51e-03 0.25 0.55
icd9 V70.0 4000 1.00 175 0.40 0.07 5.41e-09 0.28 0.52
lab Platelets 26515-7 9000 1.00 200 0.28 0.04 2.02e-14 0.21 0.35
icd9 Benign essential hypertension 401.1 4000 1.00 93 0.44 0.12 9.28e-05 0.29 0.55
lab Oxygen/Inspired gas 19993-5 800 1.00 200 0.81 0.19 5.45e-05 0.77 0.86
icd9 V72.6 3000 1.00 197 0.60 0.10 1.23e-09 0.49 0.71
lab Triglyceride 2571-8 9000 1.00 200 0.27 0.06 4.00e-07 0.17 0.37
icd9 Hypo-osmolality and or hyponatremia 276.1 3000 0.99 188 0.42 0.15 2.44e-04 0.25 0.59
icd9 Osteochondropathy 733.90 3000 0.79 157 0.28 0.13 1.91e-02 0.23 0.35
icd9 Costiveness 564.00 4000 0.99 131 0.29 0.09 2.24e-04 0.17 0.47
lab Bicarbonate 28641-9 1000 0.85 233 0.70 0.15 1.10e-05 0.34 0.99
icd9 Vitamin D deficiency 268.9 4000 1.00 82 0.39 0.08 3.00e-07 0.28 0.46
lab Erythrocyte mean corpuscular volume 787-2 5000 1.00 71 0.44 0.05 4.10e-20 0.33 0.52
lab Globulin 2336-6 9000 1.00 200 0.45 0.05 2.42e-21 0.37 0.55
icd9 Depressive disorder 311 4000 0.93 184 0.23 0.04 1.49e-03 0.15 0.36
icd9 Familial combined hyperlipidemia 272.2 3000 1.00 193 0.53 0.09 1.68e-05 0.46 0.61
lab Carbon dioxide 28645-0 5000 1.00 198 0.63 0.07 2.97e-18 0.47 0.76
icd9 Osteoporosis 733.00 4000 0.99 197 0.38 0.10 2.38e-04 0.28 0.50
icd9 Hyperlipidemia 272.4 3000 0.89 176 0.33 0.11 1.19e-03 0.20 0.52
icd9 CD - Contact dermatitis 692.9 2000 0.90 86 0.42 0.15 3.24e-03 0.28 0.56
icd9 V72.84 4000 1.00 85 0.41 0.12 7.90e-05 0.27 0.58
icd9 End stage renal disease 585.6 1000 0.90 209 0.50 0.21 4.25e-03 0.31 0.77
lab Estimated average glucose 27353-2 5000 0.96 193 0.31 0.08 5.98e-05 0.18 0.53
lab Hemoglobin A/Hemoglobin.total 20572-4 9000 1.00 147 0.93 0.11 3.58e-12 0.73 0.99
icd9 HIV counseling V65.44 3000 0.97 193 0.35 0.08 8.29e-04 0.21 0.50
icd9 HIV - Human immunodeficiency virus infection 042 1000 1.00 76 0.68 0.16 9.53e-05 0.55 0.77
lab Carbon dioxide 2021-4 5000 0.96 192 0.39 0.16 8.05e-03 0.29 0.47
lab Natriuretic peptide.B 30934-4 7000 1.00 189 0.72 0.19 7.76e-04 0.60 0.83
icd9 Needs influenza immunisation V04.81 4000 1.00 115 0.75 0.08 2.64e-37 0.60 0.93
icd9 HIV seropositivity V08 1000 0.99 70 0.47 0.25 5.88e-03 0.31 0.61
lab Glucose 2339-0 9000 1.00 199 0.54 0.06 6.59e-17 0.38 0.77
icd9 Closed fracture 829.0 4000 1.00 115 0.42 0.20 1.80e-05 0.36 0.52
lab Erythrocyte distribution width 788-0 5000 1.00 44 0.19 0.05 7.33e-05 0.13 0.32
lab Erythrocyte mean corpuscular hemoglobin concentration 786-4 5000 0.91 30 0.20 0.06 1.52e-04 0.08 0.36
icd9 Abnormal glucose level 790.29 4000 0.99 166 0.23 0.07 3.39e-03 0.16 0.31
icd9 Diaphragmatic hernia 553.3 3000 1.00 44 0.48 0.25 1.66e-03 0.40 0.56
icd9 Chest pain 786.59 4000 0.93 71 0.23 0.05 1.36e-03 0.15 0.34
icd9 Strept throat 034.0 1000 0.85 96 0.39 0.15 1.97e-03 0.23 0.55
lab Calcium.ionized 1994-3 8000 1.00 200 0.20 0.09 9.17e-03 0.15 0.27
icd9 V05.3 4000 1.00 83 0.56 0.06 3.64e-08 0.35 0.73
icd9 V05.8 2000 1.00 174 0.47 0.12 6.66e-05 0.31 0.74
icd9 V05.9 500 0.81 25 0.76 0.19 2.88e-03 0.47 0.87
lab Oxygen 28649-2 5000 1.00 200 0.44 0.07 7.23e-10 0.22 0.65
lab Chloride 2075-0 9000 0.85 168 0.14 0.04 1.27e-04 0.07 0.23
icd9 Morbid obesity 278.01 1000 0.95 99 0.51 0.17 7.48e-03 0.32 0.77
icd9 Obesity 278.00 3000 1.00 50 0.63 0.11 2.57e-17 0.55 0.81
lab Cholesterol 2093-3 9000 1.00 200 0.24 0.05 7.00e-07 0.16 0.35
lab Iron binding capacity 2500-7 9000 1.00 200 0.42 0.08 5.00e-07 0.32 0.52
icd9 Myalgia 729.1 3000 0.87 172 0.22 0.64 9.15e-03 0.15 0.36
icd9 Pain in limb 729.5 4000 0.93 186 0.20 0.05 1.78e-03 0.12 0.30
lab Erythrocytes 789-8 5000 1.00 32 0.18 0.05 2.46e-04 0.11 0.29
lab Hemoglobin A2/Hemoglobin.total 4552-6 9000 1.00 195 0.82 0.12 8.91e-09 0.64 0.96
lab Erythrocyte mean corpuscular hemoglobin 785-6 5000 1.00 57 0.47 0.05 1.49e-24 0.40 0.57
icd9 Viral disease 079.99 3000 1.00 176 0.49 0.11 1.80e-09 0.34 0.65
lab Reticulocytes/100 erythrocytes 4679-7 6000 1.00 200 0.71 0.07 1.99e-18 0.64 0.83
lab Metamyelocytes/100 leukocytes 740-1 4000 0.98 197 0.53 0.20 5.07e-03 0.39 0.66
lab Urate 3084-1 9000 0.99 199 0.31 0.10 9.25e-04 0.21 0.43
icd9 Acute upper respiratory infection 465.9 3000 1.00 188 0.31 0.08 1.33e-05 0.20 0.44
icd9 Positive skin test reaction 795.5 500 0.90 37 0.56 0.33 6.01e-03 0.39 0.75
lab IgA.secretory 14163-0 4000 1.00 59 0.68 0.18 2.64e-04 0.48 0.85
lab Monocytes/100 leukocytes 744-3 9000 1.00 200 0.29 0.08 3.91e-04 0.19 0.37
icd9 Epigastric pain 789.06 4000 0.95 35 0.23 0.12 1.84e-02 0.18 0.29
icd9 General abdominal pain-symptom 789.07 3000 0.91 148 0.30 0.19 2.08e-02 0.24 0.41
lab Iron saturation 2502-3 9000 0.86 173 0.24 0.09 6.08e-03 0.16 0.34
lab Hematocrit 20570-8 9000 0.88 176 0.08 0.03 4.15e-03 0.06 0.15
lab Iron binding capacity.unsaturated 2501-5 9000 1.00 200 0.36 0.09 2.18e-05 0.27 0.45
icd9 Dysuria 788.1 3000 0.70 138 0.20 0.05 6.27e-03 0.15 0.36
lab Glucose 2345-7 9000 0.96 192 0.17 0.04 1.56e-05 0.08 0.28
icd9 Diarrhea 787.91 4000 0.96 81 0.23 0.24 2.11e-04 0.14 0.42
lab Erythrocytes.nucleated/100 leukocytes 19048-8 5000 0.98 196 0.30 0.09 6.67e-04 0.20 0.45
icd9 V03.82 3000 1.00 135 0.37 0.14 1.14e-03 0.18 0.53
lab Cholesterol.total/Cholesterol.in HDL 9830-1 6000 1.00 75 0.36 0.06 6.69e-09 0.26 0.49
icd9 Type 2 diabetes mellitus 250.00 4000 1.00 46 0.33 0.35 3.62e-04 0.21 0.46
icd9 IgE-mediated allergic asthma 493.00 1000 0.98 238 0.38 0.13 1.20e-02 0.28 0.54
lab Carbon dioxide 2028-9 9000 1.00 200 0.22 0.04 1.00e-07 0.14 0.31
lab Oxygen saturation 2709-4 1000 1.00 400 0.78 0.16 4.30e-06 0.68 0.90
lab Gamma glutamyl transferase 2324-2 3000 0.91 181 0.41 0.19 1.67e-02 0.33 0.64
lab Carbon dioxide 16551-4 1000 1.00 393 0.83 0.16 2.10e-06 0.70 0.97
lab Lymphocytes 732-8 9000 0.73 146 0.17 0.08 2.27e-02 0.12 0.36
icd9 Abdominal pain 789.00 4000 0.76 69 0.23 0.10 4.67e-03 0.15 0.35
lab Basophils/100 leukocytes 707-0 9000 1.00 200 0.64 0.11 1.00e-07 0.34 0.79
icd9 Exacerbation of asthma 493.92 2000 0.92 170 0.28 0.24 7.82e-03 0.18 0.43
icd9 Hyperreactive airway disease 493.90 3000 1.00 184 0.34 0.08 1.40e-06 0.21 0.49
lab Platelet mean volume 28542-9 4000 0.95 42 0.26 0.06 1.60e-06 0.10 0.40
lab Carbon dioxide 2020-6 1000 0.98 393 0.44 0.17 5.57e-03 0.32 0.65
lab Thyroxine 3026-2 8000 0.99 194 0.24 0.09 3.80e-03 0.17 0.32
icd9 V76.12 4000 1.00 75 0.64 0.11 5.00e-06 0.53 0.79
icd9 V64.05 3000 0.97 108 0.39 0.08 1.92e-03 0.22 0.56
lab Oxygen 2704-5 1000 1.00 400 0.50 0.16 7.00e-04 0.44 0.63
lab Lactate 19239-3 900 1.00 196 0.56 0.18 1.41e-03 0.43 0.80
lab Monocytes 743-5 6000 0.99 198 0.17 0.07 4.67e-03 0.13 0.20
icd9 Interstitial edema 782.3 3000 0.90 178 0.33 0.15 2.33e-03 0.22 0.52
lab Oxygen 2703-7 5000 0.98 196 0.45 0.16 3.19e-03 0.33 0.54
icd9 Mitral valve disorder 424.0 4000 0.99 152 0.42 0.13 2.02e-04 0.30 0.53
lab Oxygen saturation 2708-6 8000 1.00 167 0.29 0.07 2.03e-05 0.20 0.39
icd9 Hyperlipidemia, group A 272.0 4000 0.83 30 0.27 0.11 2.77e-03 0.19 0.42
icd9 V72.60 400 0.94 34 0.71 0.34 8.47e-03 0.49 0.97
lab Calcium 17861-6 9000 0.98 197 0.18 0.04 1.30e-05 0.10 0.29
lab Albumin 14957-5 4000 0.92 161 0.75 0.17 5.62e-05 0.58 0.96
lab Monocytes/100 leukocytes 5905-5 9000 0.97 195 0.14 0.04 2.36e-04 0.09 0.21
lab Albumin 1751-7 9000 1.00 200 0.53 0.04 1.59e-30 0.42 0.63
icd9 GERD - Gastro-esophageal reflux disease 530.81 4000 1.00 164 0.27 0.08 6.14e-05 0.15 0.41
lab Potassium 6298-4 8000 1.00 200 0.37 0.10 8.39e-05 0.31 0.48
icd9 Disorders of lipoid metabolism 272.9 800 0.99 197 0.49 0.17 6.54e-03 0.37 0.62
icd9 Dental caries 521.00 600 1.00 32 0.69 0.14 1.97e-04 0.55 0.82
lab Creatinine 2161-8 9000 1.00 200 0.36 0.08 1.59e-05 0.31 0.41
icd9 Tobacco dependence syndrome 305.1 4000 0.99 121 0.26 0.32 1.15e-03 0.18 0.37
lab Urea nitrogen/Creatinine 44734-2 9000 1.00 200 0.19 0.04 1.40e-06 0.13 0.27
icd9 HA - Headache 784.0 4000 1.00 90 0.20 0.68 1.12e-03 0.12 0.29
icd9 Disorder of paranasal sinuses 478.19 3000 0.91 169 0.23 0.07 5.58e-03 0.15 0.38
lab Magnesium 19123-9 9000 1.00 200 0.32 0.05 1.81e-10 0.15 0.46
lab Reticulocytes 14196-0 7000 1.00 200 0.86 0.07 7.41e-29 0.83 0.91
lab Cells.CD3+CD4+ 24467-3 800 0.75 30 0.70 0.34 2.84e-02 0.61 0.97
icd9 Disease of teeth AND/OR supporting structures 525.8 3000 1.00 117 0.92 0.15 1.00e-47 0.87 0.99
lab Sample icteric 20392-7 9000 1.00 200 0.42 0.06 1.83e-14 0.27 0.59
icd9 Acute pharyngitis 462 3000 1.00 128 0.59 0.03 2.56e-18 0.44 0.71
lab Cholesterol.in LDL 2089-1 9000 1.00 200 0.25 0.05 2.70e-06 0.16 0.33
lab Neutrophils 26499-4 9000 1.00 200 0.19 0.04 7.10e-06 0.10 0.29
lab Creatinine 2160-0 6000 0.78 108 0.13 0.05 5.04e-03 0.06 0.28
icd9 Otalgia 388.70 2000 0.93 181 0.28 0.06 3.26e-03 0.18 0.42
icd9 Abnormal decrease in weight 783.21 4000 0.87 58 0.20 0.09 2.40e-02 0.16 0.29
icd9 Patient status finding V49.89 600 0.96 45 0.49 0.23 1.03e-03 0.32 0.60
lab HIV 1 RNA 29539-4 700 0.99 71 0.96 0.29 1.07e-02 0.79 1.00
lab Neutrophils 753-4 8000 1.00 108 0.54 0.08 3.43e-11 0.41 0.66
lab Eosinophils/100 leukocytes 26450-7 9000 0.94 187 0.12 0.03 1.51e-04 0.06 0.19
lab Bicarbonate 1961-2 1000 1.00 393 0.83 0.16 2.80e-06 0.69 0.97
icd9 Chest pain 786.50 4000 0.85 67 0.20 0.07 3.19e-03 0.12 0.30
lab Hemoglobin A1c/Hemoglobin.total 4548-4 9000 1.00 200 0.29 0.06 9.00e-07 0.19 0.41
icd9 Cervical neoplasia screening V76.2 3000 0.99 198 0.54 0.15 1.70e-04 0.34 0.75
icd9 Otitis media 382.9 3000 0.98 180 0.32 0.10 8.30e-04 0.20 0.46
lab Ferritin 2276-4 9000 0.97 189 0.49 0.10 1.40e-06 0.23 0.95
lab Cholesterol.in HDL 2085-9 9000 1.00 200 0.47 0.05 4.80e-20 0.36 0.59
icd9 Iron deficiency anaemia 280.9 3000 0.99 95 0.31 0.34 2.72e-04 0.20 0.45
lab Anion gap 33037-3 9000 0.91 181 0.13 0.04 8.17e-04 0.08 0.20
icd9 Low back pain 724.2 4000 0.83 166 0.19 0.21 9.09e-03 0.13 0.27
icd9 Fever 780.60 4000 1.00 80 0.48 0.47 2.69e-08 0.29 0.69
icd9 Backache 724.5 4000 0.80 148 0.18 0.06 7.00e-03 0.13 0.27
icd9 Hypopiesis 458.9 3000 0.96 72 0.39 0.05 3.51e-03 0.28 0.67
lab Lymphocytes/100 leukocytes 26478-8 5000 1.00 112 0.22 0.05 3.00e-06 0.12 0.30
lab Protein 2885-2 4000 1.00 133 0.51 0.06 7.45e-16 0.38 0.65
lab Iron 2498-4 9000 0.96 193 0.24 0.09 3.11e-03 0.17 0.33
lab Oxygen 28648-4 6000 0.99 86 0.26 0.07 3.07e-04 0.14 0.35
icd9 Allergic rhinitis 477.9 1000 0.98 94 0.46 0.12 3.89e-04 0.24 0.64
icd9 Cough 786.2 4000 1.00 78 0.33 0.08 1.35e-09 0.24 0.40
lab Thyroxine.free 3024-7 3000 0.93 38 0.24 0.07 1.75e-04 0.12 0.37
lab Oxygen saturation 20564-1 6000 0.97 195 0.44 0.18 1.15e-02 0.34 0.59
icd9 Urinary tract infectious disease 599.0 4000 0.70 94 0.20 0.09 4.59e-03 0.14 0.35
icd9 Shoulder joint pain 719.41 3000 0.94 185 0.28 0.08 6.99e-03 0.19 0.43
icd9 Arthralgia of the lower leg 719.46 4000 1.00 193 0.26 0.07 1.22e-03 0.17 0.35
lab Bicarbonate 28640-1 5000 1.00 192 0.53 0.08 1.69e-10 0.35 0.76
lab Lactate 59032-3 4000 0.98 190 0.74 0.14 6.00e-07 0.36 0.97
lab Creatinine 59826-8 600 0.90 177 0.84 0.38 2.89e-02 0.80 0.92
icd9 Vomiting 787.03 3000 0.95 146 0.36 0.05 1.14e-03 0.20 0.55
lab Hemoglobin 718-7 5000 0.86 117 0.12 0.04 2.87e-03 0.08 0.21
lab Phosphate 2777-1 6000 1.00 138 0.37 0.09 9.40e-06 0.18 0.56
lab Oxygen saturation 2711-0 8000 1.00 129 0.38 0.06 3.93e-09 0.31 0.45
lab Carbon dioxide 28644-3 6000 1.00 116 0.32 0.08 1.66e-05 0.22 0.42